The Potential Role of Th17 Immune Responses in Coronavirus Immunopathology and Vaccine-induced Immune Enhancement
Identifieur interne : 000158 ( 2020/Analysis ); précédent : 000157; suivant : 000159The Potential Role of Th17 Immune Responses in Coronavirus Immunopathology and Vaccine-induced Immune Enhancement
Auteurs : Peter J. Hotez ; Maria Elena Bottazzi ; David B. CorrySource :
- Microbes and Infection [ 1286-4579 ] ; 2020.
Abstract
Increasing evidence points to host Th17 inflammatory responses as contributing to the severe lung pathology and mortality of lower respiratory tract infections from coronaviruses. This includes host inflammatory and cytokine responses to COVID-19 caused by the SARS-2 coronavirus (SARS CoV2). From studies conducted in laboratory animals, there are additional concerns about immune enhancement and the role of potential host immunopathology resulting from experimental human COVID-19 vaccines. Here we summarize evidence suggesting there may be partial overlap between the underlying immunopathologic processes linked to both coronavirus infection and vaccination, and a role for Th17 in immune enhancement and eosinophilic pulmonary immunopathology. Such findings help explain the link between viral-vectored coronavirus vaccines and immune enhancement and its reduction through alum adjuvants. Additional research may also clarify links between COVID-19 pulmonary immunopathology and heart disease.
Url:
DOI: 10.1016/j.micinf.2020.04.005
PubMed: NONE
PubMed Central: 7162764
Affiliations:
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Hotez</name><affiliation><nlm:aff id="aff1">Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston TX</nlm:aff><wicri:noCountry code="subfield">Houston TX</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Department of Biology, Baylor University, Waco TX</nlm:aff><wicri:noCountry code="subfield">Waco TX</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff3">Hagler Institute of Advanced Study at Texas A&M University, College Station TX</nlm:aff><wicri:noCountry code="subfield">College Station TX</wicri:noCountry></affiliation></author><author><name sortKey="Bottazzi, Maria Elena" sort="Bottazzi, Maria Elena" uniqKey="Bottazzi M" first="Maria Elena" last="Bottazzi">Maria Elena Bottazzi</name><affiliation><nlm:aff id="aff1">Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston TX</nlm:aff><wicri:noCountry code="subfield">Houston TX</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Department of Biology, Baylor University, Waco TX</nlm:aff><wicri:noCountry code="subfield">Waco TX</wicri:noCountry></affiliation></author><author><name sortKey="Corry, David B" sort="Corry, David B" uniqKey="Corry D" first="David B." last="Corry">David B. 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Hotez</name><affiliation><nlm:aff id="aff1">Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston TX</nlm:aff><wicri:noCountry code="subfield">Houston TX</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Department of Biology, Baylor University, Waco TX</nlm:aff><wicri:noCountry code="subfield">Waco TX</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff3">Hagler Institute of Advanced Study at Texas A&M University, College Station TX</nlm:aff><wicri:noCountry code="subfield">College Station TX</wicri:noCountry></affiliation></author><author><name sortKey="Bottazzi, Maria Elena" sort="Bottazzi, Maria Elena" uniqKey="Bottazzi M" first="Maria Elena" last="Bottazzi">Maria Elena Bottazzi</name><affiliation><nlm:aff id="aff1">Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston TX</nlm:aff><wicri:noCountry code="subfield">Houston TX</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Department of Biology, Baylor University, Waco TX</nlm:aff><wicri:noCountry code="subfield">Waco TX</wicri:noCountry></affiliation></author><author><name sortKey="Corry, David B" sort="Corry, David B" uniqKey="Corry D" first="David B." last="Corry">David B. Corry</name><affiliation><nlm:aff id="aff4">Biology of Inflammation Center, Departments of Medicine and Pathology & Immunology, and the Michael E. DeBakey Center for Translational Research in Inflammatory Diseases, Baylor College of Medicine, Houston TX</nlm:aff><wicri:noCountry code="subfield">Houston TX</wicri:noCountry></affiliation></author></analytic><series><title level="j">Microbes and Infection</title><idno type="ISSN">1286-4579</idno><idno type="eISSN">1769-714X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Increasing evidence points to host Th17 inflammatory responses as contributing to the severe lung pathology and mortality of lower respiratory tract infections from coronaviruses. This includes host inflammatory and cytokine responses to COVID-19 caused by the SARS-2 coronavirus (SARS CoV2). From studies conducted in laboratory animals, there are additional concerns about immune enhancement and the role of potential host immunopathology resulting from experimental human COVID-19 vaccines. Here we summarize evidence suggesting there may be partial overlap between the underlying immunopathologic processes linked to both coronavirus infection and vaccination, and a role for Th17 in immune enhancement and eosinophilic pulmonary immunopathology. Such findings help explain the link between viral-vectored coronavirus vaccines and immune enhancement and its reduction through alum adjuvants. Additional research may also clarify links between COVID-19 pulmonary immunopathology and heart disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Murthy, S" uniqKey="Murthy S">S. Murthy</name></author><author><name sortKey="Gomersall, C D" uniqKey="Gomersall C">C.D. 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Cunningham</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bottazzi, Maria Elena" sort="Bottazzi, Maria Elena" uniqKey="Bottazzi M" first="Maria Elena" last="Bottazzi">Maria Elena Bottazzi</name><name sortKey="Corry, David B" sort="Corry, David B" uniqKey="Corry D" first="David B." last="Corry">David B. Corry</name><name sortKey="Hotez, Peter J" sort="Hotez, Peter J" uniqKey="Hotez P" first="Peter J." last="Hotez">Peter J. Hotez</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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